Criteria and Methods of Structural Optimization 87 it has been demonstrated that O.P it has been demonstrated that xenobiotic metabolites formed in the liver and other organs may be targeted to the kidney by selective transport systems~ many xenobiotics require enzymatic transformation to proximate reactive metabolites to elicit their toxic and carcinogenic effects including the organisational prerequisites Rapid growth of interest in the cognitive aspects of optimization and the increas ing demands that the present day engineer has to meet in modern design have created the need of a monographic treatment of the subject plate and lattice structures